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ORPHA:314769Disease
Also called GH and PRL cosecreting pituitary adenoma · Growth hormone and prolactin cosecreting pituitary adenoma · Somatolactotropinoma · Somatoprolactinoma
What it is
A rare, mixed, functioning pituitary adenoma characterized by the cosecretion of growth hormone and prolactin, which manifests with signs and symptoms of both acromegaly and hyperprolactinemia.
Key facts
- Age of onset
- Adolescent, Adult
- Classified as
- Disease
Signs and symptoms
Very common80–99%
26- Anterior hypopituitarism
- Arthralgia
- Broad foot
- Broad forehead
- Coarse facial features
- Cortical diaphyseal thickening of the upper limbs
- Deep palmar crease
- Deep plantar creases
- Elevated circulating growth hormone concentrationDiagnostic criterion
- Fatigue
- Full cheeks
- Hyperhidrosis
- Increased circulating prolactin concentrationDiagnostic criterion
- Joint swelling
- Large hands
- Long face
- Macrodactyly
- Macroglossia
- Macrotia
- Mandibular prognathia
- Osteoarthritis
- Tall stature
- Tapered finger
- Thickened skin
- Thick lower lip vermilion
- Wide nose
Common30–79%
27- Abnormal fingernail morphology
- Abnormality of the dentition
- Abnormal toenail morphology
- Amenorrhea
- Anxiety
- Broad jaw
- Cerebral palsy
- Depression
- Diabetes mellitus
- Dysmenorrhea
- Frontal bossing
- Galactorrhea
- Generalized hirsutism
- Hoarse voice
- Hypertension
- Hypogonadotropic hypogonadism
- Kyphosis
- Migraine
- Palpebral edema
- Paresthesia
- Pituitary adenoma
- Pituitary growth hormone cell adenomaDiagnostic criterion
- Pituitary prolactin cell adenomaDiagnostic criterion
- Sleep apnea
- Spinal canal stenosis
- Synophrys
- Widely spaced teeth
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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