Rare diseases · Sign or symptom
Widely spaced teeth
Wide-spaced teeth
HP:0000687
What it means
Increased spaces (diastemata) between most of the teeth in the same dental arch.
Wide spacing can be secondary to increased room by an unusually large dental arch, microdontia or mixed primary and secondary dentition. It should be carefully noted that slight spacing between the primary teeth is normal, so experience in evaluation is important in determining this feature. This descriptor must be distinguished from Diastema.
Rare diseases that can present with this36
Very common80–99%
9- Alazami syndrome
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Blepharophimosis-intellectual disability syndrome, Ohdo type
- Coffin-Lowry syndrome
- Cornelia de Lange syndrome
- Deafness with labyrinthine aplasia, microtia, and microdontia
- Intellectual disability-seizures-abnormal gait-facial dysmorphism syndrome
- Pierpont syndrome
- SSR4-CDG
Common30–79%
14- Acromegaly
- Angelman syndrome due to a point mutation
- Angelman syndrome due to maternal 15q11q13 deletion
- Angelman syndrome due to paternal uniparental disomy of chromosome 15
- Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome
- Cerebrooculonasal syndrome
- EEM syndrome
- Kabuki syndrome
- Mucopolysaccharidosis type 1
- Oligodontia
- Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome
- Peters plus syndrome
- Somatomammotropinoma
- Tricho-dento-osseous syndrome
Sometimes5–29%
12- 17q23.1q23.2microdeletion syndrome
- Alpha-mannosidosis
- Alpha-mannosidosis, infantile form
- Amelogenesis imperfecta
- Angelman syndrome
- Craniofacial dysplasia-short stature-ectodermal anomalies-intellectual disability syndrome
- Developmental delay-facial dysmorphism syndrome due to MED13L deficiency
- DOORS syndrome
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Generalised dental spacing · Generalised spacing of teeth · Generalized dental spacing · Generalized spacing of teeth · Multiple diastemata · Widely-spaced teeth
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.