Rare diseases · Sign or symptom
Diabetes mellitus
HP:0000819
What it means
A group of abnormalities characterized by hyperglycemia and glucose intolerance.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this107
Very common80–99%
13- Atypical Werner syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Bullous pemphigoid
- Cushing syndrome due to ectopic ACTH secretion
- Deafness-enamel hypoplasia-nail defects syndrome
- Familial partial lipodystrophy, Dunnigan type
- Familial partial lipodystrophy, Köbberling type
- PPARG-related familial partial lipodystrophy
- Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
- Pseudoleprechaunism syndrome, Patterson type
- Thiamine-responsive megaloblastic anemia syndrome
- Wolfram-like syndrome
- Wolfram syndrome
Common30–79%
27- 17q12microdeletion syndrome
- Aceruloplasminemia
- Acromegaly
- Adrenocortical carcinoma
- Ataxia-telangiectasia
- Congenital generalized lipodystrophy
- Cushing disease
- Dysbetalipoproteinemia
- Erythrokeratodermia variabilis
- Glucagonoma
- HJV or HAMP-related hemochromatosis
- HNF1B-related autosomal dominant tubulointerstitial kidney disease
- Holoprosencephaly
- Infantile multisystem neurologic-endocrine-pancreatic disease
- Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
- MELAS
- Morgagni-Stewart-Morel syndrome
- Necrobiosis lipoidica
- POEMS syndrome
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Primary triglyceride deposit cardiomyovasculopathy
- SHORT syndrome
- Somatomammotropinoma
- Somatostatinoma
- VIPoma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 4 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.