Rare diseases · Sign or symptom
Arthralgia
Joint pain
HP:0002829
What it means
Joint pain.
Arthralgia is distinct from Arthritis, which is not a symptom but a diagnosis with articular inflammation or signs of osteoarthritis.
Rare diseases that can present with this196
Very common80–99%
61- Acromegaly
- Adiposis dolorosa
- Adult-onset Still disease
- Alkaptonuria
- Arachnoiditis
- Autosomal dominant otospondylomegaepiphyseal dysplasia
- Blau syndrome
- Brachydactylous dwarfism, Mseleni type
- Chikungunya
- CHST3-related skeletal dysplasia
- CINCA syndrome
- Cold agglutinin disease
- Dermatoosteolysis, Kirghizian type
- Distal Xq28 microduplication syndrome
- Drug-induced lupus erythematosus
- Eiken syndrome
- Enthesitis-related juvenile idiopathic arthritis
- Erythema elevatum diutinum
- Fabry disease
- Familial calcium pyrophosphate deposition
- Familial Mediterranean fever
- Felty syndrome
- GM1 gangliosidosis
- Granulomatosis with polyangiitis
- Hemophilia A
- Hyperimmunoglobulinemia D with periodic fever
- Hypermobile Ehlers-Danlos syndrome
- Immunoglobulin A vasculitis
- Kienbock disease
- Ledderhose disease
- Legg-Calvé-Perthes disease
- Macrophagic myofasciitis
- Majeed syndrome
- Marshall syndrome
- Melorheostosis
- Muckle-Wells syndrome
- Multiple epiphyseal dysplasia type 4
- Multiple symmetric lipomatosis
- Nasu-Hakola disease
- Neuralgic amyotrophy
- Neurogenic thoracic outlet syndrome
- Nodular non-suppurative panniculitis
- Osteochondritis dissecans
- Paroxysmal cold hemoglobinuria
- Polymyositis
- Pyoderma gangrenosum
- Reactive arthritis
- Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
- SAPHO syndrome
- Schnitzler syndrome
- Somatomammotropinoma
- Spastic paraplegia-Paget disease of bone syndrome
- Spinal arteriovenous metameric syndrome
- Spondyloepimetaphyseal dysplasia, Irapa type
- Stickler syndrome
- Systemic-onset juvenile idiopathic arthritis
- Systemic sclerosis
- Tenosynovial giant cell tumor
- Whipple disease
- Wilson disease
- Xeroderma pigmentosum
Common30–79%
18- Aggressive systemic mastocytosis
- Angiostrongyliasis
- Antisynthetase syndrome
- Arthrochalasia Ehlers-Danlos syndrome
- Autoimmune hemolytic anemia, warm type
- Autoimmune hepatitis
- Autosomal recessive Stickler syndrome
- Babesiosis
- Behçet disease
- Boutonneuse fever
- Brucellosis
- Buerger disease
- Catastrophic antiphospholipid syndrome
- Classical-like Ehlers-Danlos syndrome type 1
- Congenital patella dislocation
- Cranio-osteoarthropathy
- Cryoglobulinemic vasculitis
- Cutaneous small vessel vasculitis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Arthralgias · Arthritic pain · Joint pains
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.