Rare diseases · Sign or symptom
Amenorrhea
Abnormal absence of menstruation
HP:0000141
What it means
Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months.
Rare diseases that can present with this27
Common30–79%
13- Adenohypophysitis
- Combined pituitary hormone deficiencies, genetic forms
- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- Familial hyperprolactinemia
- Meningioma
- Non-acquired panhypopituitarism
- Panhypophysitis
- Pituitary dermoid and epidermoid cysts
- Pituitary gigantism
- Ring chromosome 21 syndrome
- Sheehan syndrome
- Somatomammotropinoma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.