Rare diseases · Sign or symptom
Large hands
large hand
HP:0001176
Rare diseases that can present with this38
Very common80–99%
13- Acromegaly
- Coffin-Lowry syndrome
- Dermochondrocorneal dystrophy
- Intellectual disability, Wolff type
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Pituitary gigantism
- Progressive non-infectious anterior vertebral fusion
- Pseudoleprechaunism syndrome, Patterson type
- Somatomammotropinoma
- Symptomatic form of Coffin-Lowry syndrome in female carriers
- Trisomy 12p syndrome
- X-linked intellectual disability, Siderius type
- XY type gonadal dysgenesis-associated anomalies syndrome
Common30–79%
9The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Disproportionately large hands
Large hands
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.