Rare diseases · Sign or symptom
Migraine
Intermittent migraine headaches
HP:0002076
What it means
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this76
Very common80–99%
9Common30–79%
29- 17q11microdeletion syndrome
- ABetaL34V amyloidosis
- Acromegaly
- Aneurysm-osteoarthritis syndrome
- Atypical teratoid rhabdoid tumor
- Benign paroxysmal torticollis of infancy
- CADASIL
- Craniofaciofrontodigital syndrome
- Ependymoma
- Essential thrombocythemia
- Familial colorectal cancer Type X
- Familial paroxysmal ataxia
- GATA2 deficiency spectrum
- Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
- Hereditary hemorrhagic telangiectasia
- Hyperimmunoglobulinemia D with periodic fever
- Hypermobile Ehlers-Danlos syndrome
- Immunoglobulin A vasculitis
- Lynch syndrome
- Microcephaly-facial dysmorphism-ocular anomalies-multiple congenital anomalies syndrome
- Morgagni-Stewart-Morel syndrome
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
- Reversible cerebral vasoconstriction syndrome
- Somatomammotropinoma
- Spinocerebellar ataxia with epilepsy
- Subependymoma
- SUNCT syndrome
- Takayasu arteritis
- Visual snow syndrome
Sometimes5–29%
29- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Arachnoiditis
- CACH syndrome
- Catastrophic antiphospholipid syndrome
- Classic Hodgkin lymphoma
- Combined malonic and methylmalonic acidemia
- Congenital bile acid synthesis defect type 4
- Crouzon syndrome-acanthosis nigricans syndrome
and 21 more in this range
Rare1–4%
9- Autosomal dominant optic atrophy, classic form
- Autosomal dominant optic atrophy plus syndrome
- Autosomal dominant progressive external ophthalmoplegia
- Bernard-Soulier syndrome
- Capillary malformation-arteriovenous malformation
- Citrullinemia type I
- Epilepsy with auditory features
- Idiopathic intracranial hypertension
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Migraine headache · Migraine headaches
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.