Rare diseases · Sign or symptom
Hypertension
HP:0000822
What it means
The presence of chronic increased pressure in the systemic arterial system.
Hypertension is sustained elevation of resting systolic BP (140 mm Hg or higher), diastolic BP (90 mm Hg or higher), or both.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this200
Always100%
8- Adrenocortical carcinoma with pure aldosterone hypersecretion
- Ectopic aldosterone-producing tumor
- Familial hyperaldosteronism type II
- Familial hyperaldosteronism type III
- PLIN1-related familial partial lipodystrophy
- PPARG-related familial partial lipodystrophy
- Primary hyperaldosteronism-seizures-neurological abnormalities syndrome
- Primary unilateral adrenal hyperplasia
Very common80–99%
18- Apparent mineralocorticoid excess
- Atypical Werner syndrome
- Autosomal recessive polycystic kidney disease
- Brachydactyly-arterial hypertension syndrome
- Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Cystic hamartoma of lung and kidney
- Familial hyperaldosteronism type I
- Familial osteodysplasia, Anderson type
- Familial partial lipodystrophy, Köbberling type
- Fibronectin glomerulopathy
- Liddle syndrome
- LMNA-related cardiocutaneous progeria syndrome
- Nail-patella-like renal disease
- Polycythemia vera
- Preeclampsia
- Pseudohypoaldosteronism type 2
- Senior-Loken syndrome
Common30–79%
54- 17q11microdeletion syndrome
- AApoAIV amyloidosis
- Acquired aneurysmal subarachnoid hemorrhage
- Acromegaly
- Acute intermittent porphyria
- Acute interstitial pneumonia
- Adenine phosphoribosyltransferase deficiency
- Adrenocortical carcinoma
- ALECT2 amyloidosis
- Allan-Herndon-Dudley syndrome
- Alport syndrome
- Alström syndrome
- Antiphospholipid syndrome
- Aortic arch interruption
- Apert syndrome
- Argininosuccinic aciduria
- Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome
- Autosomal dominant polycystic kidney disease
- Bardet-Biedl syndrome
- C3 glomerulopathy
- Cocaine intoxication
- Cockayne syndrome type 1
- Cushing disease
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Cushing syndrome due to ectopic ACTH secretion
- Cystinuria
- Denys-Drash syndrome
- Eosinophilic granulomatosis with polyangiitis
- Extracranial carotid artery aneurysm
- Familial bicuspid aortic valve
- Familial cerebral saccular aneurysm
- Familial dysautonomia
- Familial pseudohyperkalemia
- Familial thoracic aortic aneurysm and aortic dissection
- Fatal familial insomnia
- Frasier syndrome
- Generalized arterial calcification of infancy
- Generalized glucocorticoid resistance syndrome
- Grange syndrome
- Heme oxygenase-1 deficiency
- Hereditary amyloidosis with primary renal involvement
- Hereditary pheochromocytoma-paraganglioma
- Homocystinuria due to cystathionine beta-synthase deficiency
- Homozygous familial hypercholesterolemia
- Hurler syndrome
- Hyperandrogenism due to cortisone reductase deficiency
- Idiopathic non-lupus full-house nephropathy
- IgG4-related retroperitoneal fibrosis
- Immunoglobulin-mediated membranoproliferative glomerulonephritis
- Infant botulism
- Juvenile Paget disease
- Lead poisoning
- Mercury poisoning
- Methanol poisoning
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Arterial hypertension · High blood pressure · Systemic hypertension
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.