Rare diseases · Sign or symptom
Fatigue
Tired
HP:0012378
What it means
A subjective feeling of tiredness characterized by a lack of energy and motivation.
Fatigue is distinct from muscle weakness.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this310
Very common80–99%
80- Acromegaly
- Acute adrenal insufficiency
- Addison disease
- Adiposis dolorosa
- Adult-onset Still disease
- AL amyloidosis
- Alpha-thalassemia-intellectual disability syndrome linked to chromosome 16
- Alpha-thalassemia-myelodysplastic syndrome
- Athyreosis
- Autoimmune hemolytic anemia, warm type
- Autosomal non-syndromic agammaglobulinemia
- Avian influenza
- Behçet disease
- Benign recurrent intrahepatic cholestasis
- Botulism
- Brain dopamine-serotonin vesicular transport disease
- Carney triad
- Carnitine palmitoyl transferase 1A deficiency
- Chikungunya
- Cholestasis-lymphedema syndrome
- CINCA syndrome
- Classic Hodgkin lymphoma
- Cold agglutinin disease
- Congenital hyperinsulinism due to HNF4A deficiency
- Congenital isolated ACTH deficiency
- Cystinosis
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
- Drug-induced autoimmune hemolytic anemia
- Ebstein malformation of the tricuspid valve
- Eosinophilic fasciitis
- Erdheim-Chester disease
- Essential thrombocythemia
- Fabry disease
- Familial cold urticaria
- Familial colorectal cancer Type X
- Gamma-heavy chain disease
- GATA2 deficiency spectrum
- Gaucher disease
- Gaucher disease type 3
- Generalized glucocorticoid resistance syndrome
- Giant cell arteritis
- Granulomatosis with polyangiitis
- Hughes-Stovin syndrome
- Hypermobile Ehlers-Danlos syndrome
- Iatrogenic botulism
- Infection-related hemolytic uremic syndrome
- Inhalational anthrax
- Inhalational botulism
- Juvenile dermatomyositis
- Late-onset isolated ACTH deficiency
- Legionnaires disease
- Lynch syndrome
- Macrophagic myofasciitis
- MALT lymphoma
- Menkes disease
- Methylmalonic acidemia with homocystinuria
- Methylmalonic acidemia with homocystinuria, type cblD
- Mixed connective tissue disease
- Mixed-type autoimmune hemolytic anemia
- Myelodysplastic neoplasm with increased blasts
- Nipah virus disease
- Non-insulinoma pancreatogenous hypoglycemia syndrome
- Non-syndromic agammaglobulinemia
- Oculopharyngeal muscular dystrophy
- PAPA syndrome
- Plague
- Pontiac fever
- Postorgasmic illness syndrome
- Primary familial and congenital erythrocytosis
- Reynolds syndrome
- Somatomammotropinoma
- Spontaneous periodic hypothermia
- Stevens-Johnson syndrome
- Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum
- Systemic lupus erythematosus
- Takayasu arteritis
- T-cell based immunotherapy-associated cytokine release syndrome
- Thyroid hemiagenesis
- Thyroid hypoplasia
- Toxic epidermal necrolysis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tiredness
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.