Rare diseases · Sign or symptom
Depression
HP:0000716
What it means
Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this198
Very common80–99%
13Common30–79%
63- 48,XXYY syndrome
- Acromegaly
- Alexander disease
- Alobar holoprosencephaly
- Amyotrophic lateral sclerosis
- Arginine vasopressin deficiency
- Atypical pantothenate kinase-associated neurodegeneration
- Autoimmune hepatitis
- Autoimmune limbic encephalitis
- Autosomal dominant dopa-responsive dystonia
- Autosomal recessive generalized dystrophic epidermolysis bullosa, severe form
- Bardet-Biedl syndrome
- Burning mouth syndrome
- Central neurocytoma
- Chronic hiccup
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- DNA2-related mitochondrial DNA deletion syndrome
- Familial colorectal cancer Type X
- Fatal familial insomnia
- Fragile X-associated tremor/ataxia syndrome
- Frontotemporal dementia with motor neuron disease
- Gaucher disease
- Giant cell arteritis
- Glossopharyngeal neuralgia
- Huntington disease
- Huntington disease-like 1
- Hurler syndrome
- Hypermobile Ehlers-Danlos syndrome
- Inherited Creutzfeldt-Jakob disease
- Interstitial cystitis
- Juvenile Huntington disease
- Kleine-Levin syndrome
- Lafora disease
- Lobar holoprosencephaly
- Lynch syndrome
- Maternal uniparental disomy of chromosome 4 syndrome
- Mayer-Rokitansky-Küster-Hauser syndrome
- MELAS
- Midline interhemispheric variant of holoprosencephaly
- Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
- Multiple system atrophy, cerebellar type
- Multiple system atrophy, parkinsonian type
- Myoclonus-dystonia syndrome
- Non-24-hour sleep-wake syndrome
- Normosmic congenital hypogonadotropic hypogonadism
- Oromandibular dystonia
- PANDAS
- Pellagra
- Pemphigus vulgaris
- Progressive non-fluent aphasia
- Progressive supranuclear palsy
- Progressive supranuclear palsy-predominant parkinsonism syndrome
- Renal nutcracker syndrome
- Resistance to thyrotropin-releasing hormone syndrome
- Sagliker syndrome
- Semilobar holoprosencephaly
- Somatomammotropinoma
- Spinocerebellar ataxia type 42
- Spinocerebellar ataxia with epilepsy
- Subacute sclerosing leukoencephalitis
- Tuberous sclerosis complex
- Visual snow syndrome
- Young-onset Parkinson disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Depressive disorder · Depressive episode · Depressivity
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.