Rare diseases · Sign or symptom
Hoarse voice
Hoarseness
HP:0001609
What it means
Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
Rare diseases that can present with this58
Very common80–99%
10Common30–79%
22- Acromegaly
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Charcot-Marie-Tooth disease type 4A
- Dubowitz syndrome
- FRAXE intellectual disability
- Isolated thyroid-stimulating hormone deficiency
- Keipert syndrome
- Laryngo-onycho-cutaneous syndrome
- Microduplication Xp11.22p11.23 syndrome
- Mucopolysaccharidosis type 2
- MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
- Parathyroid carcinoma
- Periodontal Ehlers-Danlos syndrome
- Relapsing polychondritis
- Resistance to thyrotropin-releasing hormone syndrome
- Richieri Costa-Pereira syndrome
- Severe generalized junctional epidermolysis bullosa
- Somatomammotropinoma
- Spondyloepimetaphyseal dysplasia, aggrecan type
- Thyroid ectopia
- Thyroid lymphoma
- Vocal cord and pharyngeal distal myopathy
Sometimes5–29%
23- Acromicric dysplasia
- Aicardi-Goutières syndrome
- Airway infantile hemangioma
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal recessive spastic paraplegia type 20
- Congenital fiber-type disproportion myopathy
- Congenital tracheomalacia
and 15 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Husky voice
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.