Rare diseases · Sign or symptom
Generalized hyperpigmentation
HP:0007440
Rare diseases that can present with this28
Very common80–99%
14- 46,XY difference of sex development-adrenal insufficiency due to CYP11A1 deficiency
- Congenital heart defect-round face-developmental delay syndrome
- Cronkhite-Canada syndrome
- Cutaneous mastocytosis-deafness-microtia syndrome
- Familial glucocorticoid deficiency
- Foveal hypoplasia-presenile cataract syndrome
- Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
- Insulin-resistance syndrome type A
- Neurocutaneous melanocytosis
- Neurofibromatosis type 1
- Oculoectodermal syndrome
- Parana hard skin syndrome
- Phakomatosis pigmentovascularis
- Triple A syndrome
Common30–79%
5Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Generalised hyperpigmentation
Generalized hyperpigmentation
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.