Rare diseases · Sign or symptom
Synophrys
Monobrow
HP:0000664
What it means
Meeting of the medial eyebrows in the midline.
Rare diseases that can present with this104
Very common80–99%
19- Amaurosis-hypertrichosis syndrome
- Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome
- Branchioskeletogenital syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Cornelia de Lange syndrome
- Difference of sex development-intellectual disability syndrome
- Facial dysmorphism-macrocephaly-myopia-Dandy-Walker malformation syndrome
- Fetal trimethadione syndrome
- Gingival fibromatosis-facial dysmorphism syndrome
- Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
- McDonough syndrome
- Microtriplication 11q24.1 syndrome
- Night blindness-skeletal anomalies-dysmorphism syndrome
- Non-distal duplication 13q syndrome
- Radioulnar synostosis-microcephaly-scoliosis syndrome
- Smith-Magenis syndrome
- Waardenburg syndrome
- X-linked intellectual disability, Cabezas type
- X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome
Common30–79%
34- 17q24.2microdeletion syndrome
- 19p13.12microdeletion syndrome
- 2q23.1microdeletion syndrome
- Acromegaly
- Autosomal recessive cerebellar ataxia due to CWF19L1 deficiency
- Bohring-Opitz syndrome
- Brachydactyly-preaxial hallux varus syndrome
- Brachytelephalangy-dysmorphism-Kallmann syndrome
- Cerebello-oculo-facio-genital syndrome
- Cerebrofaciothoracic dysplasia
- Cleft lip/palate-ectodermal dysplasia syndrome
- Edinburgh malformation syndrome
- German syndrome
- Hypospadias-intellectual disability, Goldblatt type syndrome
- Intellectual disability-cataracts-calcified pinnae-myopathy syndrome
- KBG syndrome
- Kleefstra syndrome
- Kleefstra syndrome due to 9q34 microdeletion
- Kyphoscoliotic Ehlers-Danlos syndrome
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
- Monosomy 22 syndrome
- Monosomy 9p syndrome
- Mucopolysaccharidosis type 3
- Non-syndromic metopic craniosynostosis
- Peripheral demyelinating neuropathy-central dysmyelinating leukodystrophy-Waardenburg syndrome-Hirschsprung disease
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
- Short ulna-dysmorphism-hypotonia-intellectual disability syndrome
- Somatomammotropinoma
- Waardenburg-Shah syndrome
- Waardenburg syndrome type 1
- White matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome
- Wiedemann-Rautenstrauch syndrome
- X-linked intellectual disability, Nascimento type
- XYLT1-CDG
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Synophris · Unibrow
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.