Rare diseases · Sign or symptom
Deep palmar crease
Deep palm line
HP:0006191
What it means
Excessively deep creases of the palm.
Rare diseases that can present with this15
Common30–79%
3Sometimes5–29%
7- 19p13.12microdeletion syndrome
- 20q11.2microduplication syndrome
- Blepharophimosis-intellectual disability syndrome, Verloes type
- Dihydropyrimidine dehydrogenase deficiency
- Mosaic trisomy 9 syndrome
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Trisomy 8q syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Deep palmar creases
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.