Rare diseases · Sign or symptom
Hyperhidrosis
Excessive sweating
HP:0000975
What it means
Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.
The terms hyperhidrosis and diaphoresis are often used interchangeably to describe excessive perspiration. Diaphoresis can be used to refer to excessive sweating that occurs with certain diseases (secondary hyperhidrosis). Since the HPO does not intend to provide coess for etiologies or diseases, we will use these terms interchangeably to refer to excessive perspiration without an appropriate cause such as hot and humid weather.
Rare diseases that can present with this102
Very common80–99%
28- Acromegaly
- Böök syndrome
- Brain dopamine-serotonin vesicular transport disease
- Chondroectodermal dysplasia with night blindness
- Congenital hyperinsulinism due to HNF4A deficiency
- Crisponi syndrome
- Diffuse palmoplantar keratoderma, Bothnian type
- Erdheim-Chester disease
- Familial cold urticaria
- Familial dysautonomia
- Fucosidosis
- Hereditary sensory and autonomic neuropathy type 2
- Hirschsprung disease-ganglioneuroblastoma syndrome
- Insulinoma
- MALT lymphoma
- Microcephalic primordial dwarfism, Montreal type
- Neuroleptic malignant syndrome
- Non-insulinoma pancreatogenous hypoglycemia syndrome
- Pachydermoperiostosis
- Palmoplantar keratoderma, Nagashima type
- Peripheral motor neuropathy-dysautonomia syndrome
- Pituitary gigantism
- Scrub typhus
- Somatomammotropinoma
- Spontaneous periodic hypothermia
- Stiff person spectrum disorder
- Stüve-Wiedemann syndrome
- Thyrotoxic periodic paralysis
Common30–79%
36- Adrenocortical carcinoma
- Alexander disease
- Allan-Herndon-Dudley syndrome
- Anterior cutaneous nerve entrapment syndrome
- Apert syndrome
- Aromatic L-amino acid decarboxylase deficiency
- Babesiosis
- Brucellosis
- Classic Hodgkin lymphoma
- Cocaine intoxication
- Complete atrioventricular septal defect
- Congenitally uncorrected transposition of the great arteries
- Diencephalic syndrome
- Dopa-responsive dystonia due to sepiapterin reductase deficiency
- Dyskeratosis congenita
- Episodic ataxia type 1
- Familial thrombocytosis
- Fatal familial insomnia
- Focal palmoplantar and gingival keratoderma
- Isaacs syndrome
- Keratosis palmaris et plantaris-clinodactyly syndrome
- Kleine-Levin syndrome
- Mal de Meleda
- Medullary thyroid carcinoma
- Multiple endocrine neoplasia type 2
- Narcolepsy type 1
- Naxos disease
- Osteogenesis imperfecta
- Pediatric-onset Graves disease
- Postorgasmic illness syndrome
- Spastic paraplegia-optic atrophy-neuropathy syndrome
- SUNCT syndrome
- TSH-secreting pituitary adenoma
- Tufted angioma
- Tyrosinemia type 2
- X-linked acrogigantism
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Diaphoresis · Increased sweating · Profuse sweating · Sweating · Sweating profusely · Sweating, increased
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.