Rare diseases · Sign or symptom
Paresthesia
Pins and needles feeling
HP:0003401
What it means
Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause.
Rare diseases that can present with this107
Very common80–99%
16- ABetaL34V amyloidosis
- Arachnoiditis
- Autosomal dominant hypocalcemia
- Chronic inflammatory demyelinating polyneuropathy
- Congenital cataracts-facial dysmorphism-neuropathy syndrome
- Essential thrombocythemia
- Facial onset sensory and motor neuronopathy
- Hereditary angioedema type 1
- Ledderhose disease
- Neurogenic thoracic outlet syndrome
- Phakomatosis pigmentovascularis
- Progeria-short stature-pigmented nevi syndrome
- Rabies
- Stüve-Wiedemann syndrome
- Thiamine-responsive megaloblastic anemia syndrome
- Thoracic outlet syndrome
Common30–79%
31- Acromegaly
- Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
- Acute peripheral arterial occlusion
- Adrenocortical carcinoma with pure aldosterone hypersecretion
- Angiostrongyliasis
- Autoimmune hypoparathyroidism
- Autosomal dominant optic atrophy and cataract
- Autosomal recessive progressive external ophthalmoplegia
- Buerger disease
- Familial cerebral cavernous malformation
- Familial or sporadic hemiplegic migraine
- Familial thrombocytosis
- Gerstmann-Straussler-Scheinker syndrome
- Hereditary neuropathy with liability to pressure palsies
- Leprosy
- Localized epidermolysis bullosa simplex
- Mitochondrial neurogastrointestinal encephalomyopathy
- Mucopolysaccharidosis type 1
- Multiple symmetric lipomatosis
- Neuralgic amyotrophy
- Neurofibromatosis type 1
- Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity
- Paroxysmal exertion-induced dyskinesia
- POEMS syndrome
- Polycythemia vera
- Scorpion envenomation
- Secondary syringomyelia
- Somatomammotropinoma
- Trigeminal neuralgia
- Visual snow syndrome
- Wild type ABeta2M amyloidosis
Sometimes5–29%
33- Acute transverse myelitis
- Adiposis dolorosa
- African trypanosomiasis
- Alpha-N-acetylgalactosaminidase deficiency type 1
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal dominant spastic paraplegia type 10
- Autosomal recessive axonal neuropathy with neuromyotonia
and 25 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Paresthesias · Tingling
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.