Rare diseases · Sign or symptom
Increased circulating prolactin concentration
HP:0000870
What it means
The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy.
Rare diseases that can present with this35
Common30–79%
15- Acromegaly
- Adenohypophysitis
- Carney complex
- Craniopharyngioma
- Isolated thyroid-stimulating hormone deficiency
- Laron syndrome with immunodeficiency
- Meningioma
- Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
- Panhypophysitis
- Pituitary deficiency due to Rathke cleft cysts
- Pituitary dermoid and epidermoid cysts
- Pituitary gigantism
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Resistance to thyrotropin-releasing hormone syndrome
- Wiedemann-Rautenstrauch syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperprolactinaemia · Hyperprolactinemia · Prolactin excess
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.