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Start free with EleplanHypermobile Ehlers-Danlos syndrome
ORPHA:285Disease
Also called EDS III · EDS-HT · Ehlers-Danlos syndrome hypermobility type · Ehlers-Danlos syndrome type 3 · Hypermobile EDS · hEDS
What it is
Ehlers-Danlos syndrome, hypermobility type (HT-EDS) is the most frequent form of EDS, a group of hereditary connective tissue diseases, and is characterized by joint hyperlaxity, mild skin hyperextensibility, tissue fragility and extra-musculoskeletal manifestations.
Key facts
- Prevalence
- 1-5 / 10 000 (Europe)
- Age of onset
- All ages
- Inheritance
- Autosomal dominant, Autosomal recessive
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
13Common30–79%
23- Anxiety
- ArachnodactylyDiagnostic criterion
- Arrhythmia
- Atrophic scarsDiagnostic criterion
- Bruising susceptibility
- Chronic pain
- Constipation
- Decreased nerve conduction velocity
- Dental crowdingDiagnostic criterion
- Depression
- Femoral herniaDiagnostic criterion
- Malabsorption
- Migraine
- Mitral valve prolapseDiagnostic criterion
- Nausea and vomiting
- Osteoarthritis
- Pelvic organ prolapseDiagnostic criterion
- Pes planus
- Piezogenic pedal papulesDiagnostic criterion
- Rectal prolapseDiagnostic criterion
- Soft skinDiagnostic criterion
- Striae distensaeDiagnostic criterion
- Thin skin
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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