Rare diseases · Sign or symptom
Generalized joint hypermobility
Hypermobility of all joints
HP:0002761
What it means
Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body. In individuals with Joint hypermobility at multiple sites (usually five or more), the term generalized joint hypermobility is preferred.
Rare diseases that can present with this27
Very common80–99%
12- Arthrochalasia Ehlers-Danlos syndrome
- Autosomal recessive cutis laxa type 2, classic type
- Classical Ehlers-Danlos syndrome
- Classical-like Ehlers-Danlos syndrome type 1
- De Barsy syndrome
- Dermatosparaxis Ehlers-Danlos syndrome
- Dysspondyloenchondromatosis
- Hypermobile Ehlers-Danlos syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome
- Musculocontractural Ehlers-Danlos syndrome
- Spondylodysplastic Ehlers-Danlos syndrome
- Wrinkly skin syndrome
Common30–79%
8- Distal deletion 15q syndrome
- Familial anetoderma
- FG syndrome type 1
- Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
- Pseudoachondroplasia
- Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type
Sometimes5–29%
6The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Generalised joint laxity · Generalized joint laxity · Joint laxity, generalised · Joint laxity, generalized
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.