Rare diseases · Sign or symptom
Myalgia
Muscle ache
HP:0003326
What it means
Pain in muscle.
Rare diseases that can present with this177
Very common80–99%
39- Acetazolamide-responsive myotonia
- Adenosine monophosphate deaminase deficiency
- Anoctamin-5-related limb-girdle muscular dystrophy R12
- Antisynthetase syndrome
- Avian influenza
- Becker muscular dystrophy
- Behçet disease
- Carnitine palmitoyltransferase II deficiency
- Carnitine palmitoyl transferase II deficiency, myopathic form
- CINCA syndrome
- Cutaneous small vessel vasculitis
- Dermatomyositis
- Drug-induced lupus erythematosus
- Eosinophilic fasciitis
- Fabry disease
- Familial cold urticaria
- Familial Mediterranean fever
- Glycogen storage disease due to muscle and heart glycogen synthase deficiency
- Hyperimmunoglobulinemia D with periodic fever
- Hypermobile Ehlers-Danlos syndrome
- Juvenile dermatomyositis
- Legionnaires disease
- Lujo hemorrhagic fever
- Macrophagic myofasciitis
- Mixed connective tissue disease
- Muscular pseudohypertrophy-hypothyroidism syndrome
- Neurogenic thoracic outlet syndrome
- Nipah virus disease
- Nodular non-suppurative panniculitis
- Pontiac fever
- Proximal myotonic myopathy
- Pyoderma gangrenosum
- Pyomyositis
- Reynolds syndrome
- Schnitzler syndrome
- Scrub typhus
- Systemic sclerosis
- Tubular aggregate myopathy
- Tumor necrosis factor receptor 1 associated periodic syndrome
Common30–79%
41- 22q11.2deletion syndrome
- Abetalipoproteinemia
- Acyl-CoA dehydrogenase 9 deficiency
- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Adult-onset distal myopathy due to VCP mutation
- Adult-onset nemaline myopathy
- Adult-onset Still disease
- American trypanosomiasis
- Angiostrongyliasis
- Babesiosis
- Bacterial toxic-shock syndrome
- Boutonneuse fever
- Carnitine palmitoyl transferase II deficiency, severe infantile form
- Charcot-Marie-Tooth disease type 4C
- Chikungunya
- Congenital muscular dystrophy without intellectual disability
- Congenital patella dislocation
- Crimean-Congo hemorrhagic fever
- Cryoglobulinemic vasculitis
- Desmoid tumor
- DNA2-related mitochondrial DNA deletion syndrome
- Encephalitis lethargica
- Febrile infection-related epilepsy syndrome
- Glycogen storage disease due to acid maltase deficiency
- Glycogen storage disease due to aldolase A deficiency
- Glycogen storage disease due to lactate dehydrogenase deficiency
- Glycogen storage disease due to muscle beta-enolase deficiency
- Glycogen storage disease due to muscle phosphorylase kinase deficiency
- Glycogen storage disease due to phosphoglycerate mutase deficiency
- Hemorrhagic fever-renal syndrome
- Hyperkalemic periodic paralysis
- Idiopathic acute eosinophilic pneumonia
- Immune-mediated necrotizing myopathy
- Immune-mediated thrombotic thrombocytopenic purpura
- Immunoglobulin A vasculitis
- Intellectual disability-hyperkinetic movement-truncal ataxia syndrome
- Japanese encephalitis
- Laing distal myopathy
- Leptospirosis
- Listeriosis
- Majeed syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Muscle pain · Myalgias
Myalgia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.