Rare diseases · Sign or symptom
Wormian bones
Extra bones within cranial sutures
HP:0002645
What it means
The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium.
Irregular, isolated bones in the lambdoidal suture or at the fontanelles.
Rare diseases that can present with this28
Very common80–99%
12- Bruck syndrome
- Cleidocranial dysplasia
- Craniometadiaphyseal dysplasia, wormian bone type
- De Barsy syndrome
- Grant syndrome
- Hereditary sensory and autonomic neuropathy type 2
- Hypermobile Ehlers-Danlos syndrome
- Lateral meningocele syndrome
- Mandibuloacral dysplasia with type A lipodystrophy
- Osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome
- Short stature-wormian bones-dextrocardia syndrome
- Wrinkly skin syndrome
Common30–79%
4Sometimes5–29%
11- Arthrochalasia Ehlers-Danlos syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Craniofacial dysostosis-diaphyseal hyperplasia syndrome
- Dysplastic cortical hyperostosis, Al-Gazali type
- Kagami-Ogata syndrome due to paternal uniparental disomy of chromosome 14
- Osteogenesis imperfecta
- Osteoporosis-pseudoglioma syndrome
- Pycnodysostosis
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Intra sutural bones · Intrasutural bones · Islands of bone within cranial sutures
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.