Rare diseases · Sign or symptom
Bruising susceptibility
Bruise easily
HP:0000978
What it means
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
An ecchymosis is defined as being larger than 1 cm in size.
Rare diseases that can present with this80
Very common80–99%
18- Attenuated Chédiak-Higashi syndrome
- Autoerythrocyte sensitization syndrome
- Bleeding disorder in hemophilia A carriers
- Classical-like Ehlers-Danlos syndrome type 1
- Classical-like Ehlers-Danlos syndrome type 2
- Congenital fibrinogen deficiency
- Cutaneous collagenous vasculopathy
- Dermatosparaxis Ehlers-Danlos syndrome
- Gray platelet syndrome
- Immunoglobulin A vasculitis
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Musculocontractural Ehlers-Danlos syndrome
- Periodontal Ehlers-Danlos syndrome
- Polycythemia vera
- SLC39A13-related spondylodysplastic Ehlers-Danlos syndrome
- Wilson disease
- Wiskott-Aldrich syndrome
- X-linked Ehlers-Danlos syndrome
Common30–79%
34- Acute liver failure
- Acute promyelocytic leukemia
- AGel amyloidosis
- Alpha-thalassemia-intellectual disability syndrome linked to chromosome 16
- Alpha-thalassemia-myelodysplastic syndrome
- Aneurysm-osteoarthritis syndrome
- Autoimmune lymphoproliferative syndrome
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Cardiac-valvular Ehlers-Danlos syndrome
- Chédiak-Higashi syndrome
- Combined deficiency of factor V and factor VIII
- Congenital factor VII deficiency
- Congenital factor XIII deficiency
- Cushing disease
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Cushing syndrome due to ectopic ACTH secretion
- Evans syndrome
- GATA2 deficiency spectrum
- Gaucher disease type 1
- Glanzmann thrombasthenia
- Hereditary combined deficiency of vitamin K-dependent clotting factors
- Hermansky-Pudlak syndrome
- Hypermobile Ehlers-Danlos syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome due to FKBP22 deficiency
- Marshall-Smith syndrome
- MYH9-related syndromic thrombocytopenia
- Occipital horn syndrome
- Pseudoxanthoma elasticum
- RIN2 syndrome
- Scott syndrome
- Severe hemophilia A
- Vascular Ehlers-Danlos syndrome
- Von Willebrand disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Bruisability · Easy bruisability · Easy bruising
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.