Rare diseases · Sign or symptom
Nausea and vomiting
HP:0002017
What it means
Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this140
Very common80–99%
44- Acute adrenal insufficiency
- Addison disease
- Alexander disease
- Atypical teratoid rhabdoid tumor
- Behçet disease
- Carney triad
- Cholestasis-lymphedema syndrome
- CINCA syndrome
- Dracunculiasis
- Encephalopathy due to sulfite oxidase deficiency
- Episodic ataxia type 6
- Familial Mediterranean fever
- Galactose epimerase deficiency
- Hemangioblastoma
- Hereditary folate malabsorption
- Hirschsprung disease
- Holocarboxylase synthetase deficiency
- Hydatidiform mole
- Immunoglobulin A vasculitis
- Junctional epidermolysis bullosa with pyloric atresia
- L1 syndrome
- Late-onset isolated ACTH deficiency
- Lhermitte-Duclos disease
- Lysosomal acid lipase deficiency
- Malaria
- MALT lymphoma
- Megacystis-microcolon-intestinal hypoperistalsis syndrome
- Nipah virus disease
- Nodular non-suppurative panniculitis
- Ovarian hyperstimulation syndrome
- Palmoplantar keratoderma-esophageal carcinoma syndrome
- Papillary tumor of the pineal region
- Pineocytoma
- Pituitary dermoid and epidermoid cysts
- Primary peritoneal carcinoma
- Rabies
- Rheumatic fever
- Spontaneous periodic hypothermia
- Stevens-Johnson syndrome
- Vitamin B12-responsive methylmalonic acidemia
- Vitamin B12-unresponsive methylmalonic acidemia
- Vitamin B12-unresponsive methylmalonic acidemia type mut0
- Wolman disease
- Xp21deletion syndrome
Common30–79%
36- Acute intermittent porphyria
- Adenocarcinoma of the oesophagus and oesophagogastric junction
- Arginine vasopressin resistance
- Benign recurrent intrahepatic cholestasis
- Botulism
- Central neurocytoma
- Cholesteryl ester storage disease
- Craniopharyngioma
- Crimean-Congo hemorrhagic fever
- Cystinuria
- Desmoplastic small round cell tumor
- Eosinophilic granulomatosis with polyangiitis
- Fabry disease
- Familial cold urticaria
- Familial colorectal cancer Type X
- Familial hypoaldosteronism
- Familial paroxysmal ataxia
- Foodborne botulism
- Gastrointestinal stromal tumor
- GATA2 deficiency spectrum
- Glucagonoma
- Granulomatosis with polyangiitis
- GRFoma
- Hall-Riggs syndrome
- Hereditary angioedema with C1Inh deficiency
- Hereditary ATTR amyloidosis
- Herpes simplex virus encephalitis
- High altitude pulmonary edema
- Hughes-Stovin syndrome
- Hypermobile Ehlers-Danlos syndrome
- Hypocomplementemic urticarial vasculitis
- Inhalational botulism
- Intestinal botulism
- Lassa fever
- Leptospirosis
- Limited cutaneous systemic sclerosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.