Rare diseases · Sign or symptom
Acrocyanosis
Persistent blue color of hands or feet
HP:0001063
What it means
Bluish discoloration of the skin of the hands or feet.
Cyanosis is caused by increased levels of deoxygenated hemoglobin.
Rare diseases that can present with this25
Very common80–99%
4Common30–79%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Persistent blue colour of hands or feet
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.