Rare diseases · Sign or symptom
Arrhythmia
Abnormal heart rate
HP:0011675
What it means
Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this153
Very common80–99%
16- Atrial septal defect-atrioventricular conduction defects syndrome
- Carnitine-acylcarnitine translocase deficiency
- Heart-hand syndrome, Slovenian type
- Heart-hand syndrome type 2
- Hirschsprung disease-ganglioneuroblastoma syndrome
- His bundle tachycardia
- Idiopathic neonatal atrial flutter
- Liddle syndrome
- Nathalie syndrome
- Naxos disease
- Noonan syndrome with multiple lentigines
- Spondylometaphyseal dysplasia, Sedaghatian type
- Subaortic stenosis-short stature syndrome
- Sudden infant death-dysgenesis of the testes syndrome
- Supravalvular aortic stenosis
- Ventricular extrasystoles with syncopal episodes-perodactyly-Robin sequence syndrome
Common30–79%
43- 19p13.12microdeletion syndrome
- AGel amyloidosis
- American trypanosomiasis
- ATTRV122I amyloidosis
- ATTRV30M amyloidosis
- Autosomal dominant Charcot-Marie-Tooth disease type 2K
- Autosomal dominant hypocalcemia
- Barth syndrome
- Botulism
- Cardiogenic shock
- Cardiomyopathy-cataract-hip spine disease syndrome
- Carnitine palmitoyl transferase II deficiency, neonatal form
- Colchicine poisoning
- Deafness-enamel hypoplasia-nail defects syndrome
- Ebstein malformation of the tricuspid valve
- Familial idiopathic dilatation of the right atrium
- Familial isolated dilated cardiomyopathy
- Familial isolated hypoparathyroidism
- Foodborne botulism
- Glycogen storage disease with severe cardiomyopathy due to glycogenin deficiency
- GNB5-related intellectual disability-cardiac arrhythmia syndrome
- HEC syndrome
- Hereditary ATTR amyloidosis
- Hereditary progressive cardiac conduction defect
- Hypermobile Ehlers-Danlos syndrome
- Isolated ATP synthase deficiency
- Isolated atrial standstill
- Jervell and Lange-Nielsen syndrome
- Kleefstra syndrome
- Legionnaires disease
- Microphthalmia with linear skin defects syndrome
- Noonan syndrome
- Primary triglyceride deposit cardiomyovasculopathy
- Propionic acidemia
- Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
- Rheumatic fever
- Spontaneous periodic hypothermia
- Stickler syndrome
- Symmetrical thalamic calcifications
- Tropical endomyocardial fibrosis
- Typhoid
- Wild type ATTR amyloidosis
- Wiskott-Aldrich syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Arrhythmias · Cardiac arrhythmia · Cardiac arrhythmias · Cardiac rhythm disturbances · Heart rhythm disorders · Irregular heart beat · Irregular heartbeat
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.