Rare diseases · Sign or symptom
Arachnodactyly
Long slender fingers
HP:0001166
What it means
Abnormally long and slender fingers (spider fingers).
Rare diseases that can present with this85
Very common80–99%
25- 15q overgrowth syndrome
- Antley-Bixler syndrome
- Arthrogryposis-like hand anomaly-sensorineural deafness syndrome
- B4GALT7-related spondylodysplastic Ehlers-Danlos syndrome
- Blindness-scoliosis-arachnodactyly syndrome
- Cohen syndrome
- Congenital contractural arachnodactyly
- Cryptorchidism-arachnodactyly-intellectual disability syndrome
- Cutis laxa-Marfanoid syndrome
- Distal 16p11.2 microdeletion syndrome
- Distal deletion 19p syndrome
- Distal duplication 15q syndrome
- Fryns-Smeets-Thiry syndrome
- Hamel cerebro-palato-cardiac syndrome
- Harrod syndrome
- Homocystinuria due to cystathionine beta-synthase deficiency
- Hydrocephaly-tall stature-joint laxity syndrome
- Marden-Walker syndrome
- Marfan syndrome
- Megalencephaly-severe kyphoscoliosis-overgrowth syndrome
- Neonatal Marfan syndrome
- Oculocerebrofacial syndrome, Kaufman type
- Proximal 16p11.2 microduplication syndrome
- Shprintzen-Goldberg syndrome
- Van den Ende-Gupta syndrome
Common30–79%
33- 22q11.2deletion syndrome
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome
- Aneurysm-osteoarthritis syndrome
- Arachnodactyly-abnormal ossification-intellectual disability syndrome
- Arthrogryposis-oculomotor limitation-electroretinal anomalies syndrome
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Beta-mercaptolactate cysteine disulfiduria
- Contractures-developmental delay-Pierre Robin syndrome
- Distal duplication 18q syndrome
- Ectodermal dysplasia-sensorineural deafness syndrome
- Haim-Munk syndrome
- Hypermobile Ehlers-Danlos syndrome
- Hypotonia-speech impairment-severe cognitive delay syndrome
- Imperforate oropharynx-costovertebral anomalies syndrome
- Koolen-De Vries syndrome
- Loeys-Dietz syndrome
- Lujan-Fryns syndrome
- Marfanoid habitus-autosomal recessive intellectual disability syndrome
- Microcephaly-glomerulonephritis-marfanoid habitus syndrome
- Monosomy 18q syndrome
- Multiple pterygium-malignant hyperthermia syndrome
- Non-distal duplication 13q syndrome
- Oculocerebral hypopigmentation syndrome, Cross type
- Oculocerebral hypopigmentation syndrome, Preus type
- Paraplegia-intellectual disability-hyperkeratosis syndrome
- Prolidase deficiency
- Short stature-craniofacial anomalies-genital hypoplasia syndrome
- Stickler syndrome
- Trisomy 1q syndrome
- Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome
- Wolf-Hirschhorn syndrome
- X-linked intellectual disability, Snyder type
Sometimes5–29%
22- 10q22.3q23.3microdeletion syndrome
- 16p13.11microduplication syndrome
- 2q32q33deletion syndrome
- Arterial tortuosity syndrome
- Bainbridge-Ropers syndrome
- Brittle cornea syndrome
- Classical-like Ehlers-Danlos syndrome type 2
- Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
and 14 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Long, slender fingers · Spider fingers
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.