Rare diseases · Sign or symptom
Abnormal autonomic nervous system physiology
HP:0012332
What it means
A functional abnormality of the autonomic nervous system.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this57
Very common80–99%
13- Adult-onset autosomal dominant leukodystrophy
- Combined oxidative phosphorylation defect type 29
- Fatal familial insomnia
- Haddad syndrome
- Lambert-Eaton myasthenic syndrome
- Mutilating hereditary sensory neuropathy with spastic paraplegia
- Neuroleptic malignant syndrome
- Obesity due to SIM1 deficiency
- Pure autonomic failure
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Stüve-Wiedemann syndrome
- Sudden infant death-dysgenesis of the testes syndrome
- Trisomy 20p syndrome
Common30–79%
22- Acute transverse myelitis
- Alexander disease type II
- Alternating hemiplegia of childhood
- ATTRV30M amyloidosis
- Beta-propeller protein-associated neurodegeneration
- Caribbean parkinsonism
- Fragile X-associated tremor/ataxia syndrome
- Hereditary ATTR amyloidosis
- Inherited Creutzfeldt-Jakob disease
- Leprosy
- Multiple system atrophy
- Multiple system atrophy, cerebellar type
- Multiple system atrophy, parkinsonian type
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome
- NMDA receptor encephalitis
- Parkinsonian-pyramidal syndrome
- Ramos-Arroyo syndrome
- Spinal cord injury
- Sporadic adult-onset ataxia of unknown etiology
- Subacute sclerosing leukoencephalitis
- VPS11-related autosomal recessive hypomyelinating leukodystrophy
- Wild type ATTR amyloidosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Autonomic dysfunction · Autonomic dysregulation · Dysautonomia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.