Rare diseases · Sign or symptom
Decreased nerve conduction velocity
HP:0000762
What it means
A reduction in the speed at which electrical signals propagate along the axon of a neuron.
Nerve conduction velocity is usually measured with surface electrodes placed on the skin over nerves at various locations. Following stimulation at one electrode, the speed at which the signal is propagated to other electrodes is recorded. Abnormal values may suggest demyelination, a conduction block, or axonopathy.
Rare diseases that can present with this41
Very common80–99%
11- Cataract-ataxia-deafness syndrome
- Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome
- Charcot-Marie-Tooth disease type 1E
- Charcot-Marie-Tooth disease type 1F
- Charcot-Marie-Tooth disease type 4A
- Chronic inflammatory demyelinating polyneuropathy
- Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria
- Polyneuropathy-intellectual disability-acromicria-premature menopause syndrome
- Subacute inflammatory demyelinating polyneuropathy
- X-linked Charcot-Marie-Tooth disease type 4
- X-linked Charcot-Marie-Tooth disease type 6
Common30–79%
21- Acromicric dysplasia
- Ataxia-deafness-intellectual disability syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2K
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Cerebrotendinous xanthomatosis
- Charcot-Marie-Tooth disease type 1B
- Cockayne syndrome
- Hypermobile Ehlers-Danlos syndrome
- Infantile Krabbe disease
- Infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome
- Late-infantile/juvenile Krabbe disease
- Metachromatic leukodystrophy
- Metachromatic leukodystrophy, adult form
- Metachromatic leukodystrophy, juvenile form
- Metachromatic leukodystrophy, late infantile form
- MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect
- Mucopolysaccharidosis type 2
- MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
- Null syndrome
- Sialidosis type 1
- Wild type ABeta2M amyloidosis
Sometimes5–29%
7The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased NCV · Decreased nerve conduction velocities · Delayed nerve conduction velocity · Reduced nerve conduction velocities · Slow nerve conduction velocity · Slowed nerve conduction velocities
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.