Rare diseases · Sign or symptom
Hyperextensible skin
Hyperelastic skin
HP:0000974
What it means
A condition in which the skin can be stretched beyond normal, and then returns to its initial position.
Skin hyperelasticity is to be distinguished from cutis laxa, which refers to extra, redundant skin which tends to hang in folds.
Rare diseases that can present with this45
Very common80–99%
21- ALDH18A1-related De Barsy syndrome
- Arthrochalasia Ehlers-Danlos syndrome
- Autosomal dominant cutis laxa
- B4GALT7-related spondylodysplastic Ehlers-Danlos syndrome
- Cardiac-valvular Ehlers-Danlos syndrome
- Classical Ehlers-Danlos syndrome
- Classical-like Ehlers-Danlos syndrome type 2
- Dermatosparaxis Ehlers-Danlos syndrome
- GAPO syndrome
- Geroderma osteodysplastica
- Hypermobile Ehlers-Danlos syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome due to FKBP22 deficiency
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Menkes disease
- Musculocontractural Ehlers-Danlos syndrome
- Noonan syndrome with multiple lentigines
- Occipital horn syndrome
- RIN2 syndrome
- SLC39A13-related spondylodysplastic Ehlers-Danlos syndrome
- Spinocerebellar ataxia-dysmorphism syndrome
- X-linked Ehlers-Danlos syndrome
Common30–79%
10- Aarskog-Scott syndrome
- Arterial tortuosity syndrome
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Barber-Say syndrome
- Brittle cornea syndrome
- Cardiofaciocutaneous syndrome
- Fountain syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome
- Periodontal Ehlers-Danlos syndrome
- Spondylodysplastic Ehlers-Danlos syndrome
Sometimes5–29%
10- Autosomal recessive faciodigitogenital syndrome
- Diastrophic dysplasia
- Donohue syndrome
- Gabriele-de Vries syndrome
- Growth delay-intellectual disability-hepatopathy syndrome
- Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome
- Myopathic Ehlers-Danlos syndrome
- Pseudoxanthoma elasticum
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Skin hyperelasticity · Skin hyperextensibility · Stretchable skin
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.