Rare diseases · Sign or symptom
Thin skin
HP:0000963
What it means
Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.
Rare diseases that can present with this50
Very common80–99%
26- Absence of fingerprints-congenital milia syndrome
- Acrogeria
- ADULT syndrome
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Arthrochalasia Ehlers-Danlos syndrome
- Atypical Werner syndrome
- Autosomal dominant hypohidrotic ectodermal dysplasia
- B4GALT7-related spondylodysplastic Ehlers-Danlos syndrome
- De Barsy syndrome
- Dermatosparaxis Ehlers-Danlos syndrome
- Dermoodontodysplasia
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome
- Geroderma osteodysplastica
- Hereditary acrokeratotic poikiloderma
- Mandibuloacral dysplasia
- Mandibuloacral dysplasia with type A lipodystrophy
- Mandibuloacral dysplasia with type B lipodystrophy
- Marshall-Smith syndrome
- Oculocerebral hypopigmentation syndrome, Cross type
- Paternal 20q13.2q13.3 microdeletion syndrome
- Prolidase deficiency
- Pseudoprogeria syndrome
- SLC39A13-related spondylodysplastic Ehlers-Danlos syndrome
- Superficial epidermolytic ichthyosis
- Xeroderma pigmentosum
- X-linked Ehlers-Danlos syndrome
Common30–79%
21- 19q13.11microdeletion syndrome
- Ablepharon macrostomia syndrome
- Arterial tortuosity syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Cardiac-valvular Ehlers-Danlos syndrome
- Classical-like Ehlers-Danlos syndrome type 1
- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- Familial partial lipodystrophy, Dunnigan type
- Focal dermal hypoplasia
- Hypermobile Ehlers-Danlos syndrome
- Localized dystrophic epidermolysis bullosa, acral form
- Periodontal Ehlers-Danlos syndrome
- Periventricular nodular heterotopia
- PPARG-related familial partial lipodystrophy
- Severe hereditary thrombophilia due to congenital protein C deficiency
- Severe hereditary thrombophilia due to congenital protein S deficiency
- Spondylodysplastic Ehlers-Danlos syndrome
- Vascular Ehlers-Danlos syndrome
- Wiedemann-Rautenstrauch syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.