Rare diseases · Sign or symptom
Constipation
HP:0002019
What it means
Infrequent or difficult evacuation of feces.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this203
Very common80–99%
30- Acute adrenal insufficiency
- Addison disease
- Athyreosis
- Cap polyposis
- DDOST-CDG
- Familial colorectal cancer Type X
- Familial Mediterranean fever
- Foodborne botulism
- Hirschsprung disease
- Infant botulism
- Infantile nephropathic cystinosis
- Inhalational botulism
- Intellectual disability-epilepsy-extrapyramidal syndrome
- Intellectual disability-seizures-macrocephaly-obesity syndrome
- Late-onset isolated ACTH deficiency
- Liddle syndrome
- Lynch syndrome
- Muscular pseudohypertrophy-hypothyroidism syndrome
- Peripheral demyelinating neuropathy-central dysmyelinating leukodystrophy-Waardenburg syndrome-Hirschsprung disease
- Peritoneal inclusion cyst
- Pitt-Hopkins syndrome
- Primary peritoneal carcinoma
- Propionic acidemia
- Thyroid ectopia
- Thyroid hemiagenesis
- Thyroid hypoplasia
- Toxin-mediated infectious botulism
- Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome
- Waardenburg-Shah syndrome
- Wound botulism
Common30–79%
50- 13q12.3microdeletion syndrome
- 1p36deletion syndrome
- 22q11.2deletion syndrome
- 2q23.1microdeletion syndrome
- 48,XXXY syndrome
- 48,XXYY syndrome
- 49,XXXXY syndrome
- 9q33.3q34.11microdeletion syndrome
- Acute intermittent porphyria
- Alexander disease
- Alobar holoprosencephaly
- Alternating hemiplegia of childhood
- Angelman syndrome
- Angelman syndrome due to maternal 15q11q13 deletion
- Angiostrongyliasis
- Arginine vasopressin resistance
- ATTRV30M amyloidosis
- Autosomal recessive dopa-responsive dystonia
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Autosomal recessive spastic paraplegia type 20
- Axial mesodermal dysplasia spectrum
- Botulism
- CDKL5-deficiency disorder
- Christianson syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Congenital hypothyroidism due to maternal intake of antithyroid drugs
- Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies
- Congenital sucrase-isomaltase deficiency
- DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
- Emanuel syndrome
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to WAC point mutation
- Familial adenomatous polyposis
- Familial glucocorticoid deficiency
- Familial thyroid dyshormonogenesis
- Focal dermal hypoplasia
- FOXG1 syndrome
- FOXP1 Syndrome
- Gastrointestinal stromal tumor
- Glucagonoma
- GRFoma
- Hereditary ATTR amyloidosis
- Hypermobile Ehlers-Danlos syndrome
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Hypotonia-speech impairment-severe cognitive delay syndrome
- Iatrogenic botulism
- Idiopathic congenital hypothyroidism
- Infantile dystonia-parkinsonism
- Isolated thyroid-stimulating hormone deficiency
- Jacobsen syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Costiveness · Dyschezia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.