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Start free with EleplanFamilial Mediterranean fever
ORPHA:342Disease
Also called Benign paroxysmal peritonitis · Benign recurrent polyserositis · FMF · Familial paroxysmal polyserositis · Periodic disease
What it is
Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent short episodes of fever and serositis resulting in pain in the abdomen, chest, joints and muscles.
Key facts
- Prevalence
- >1 / 1000 (Armenia)
- Age of onset
- Adolescent, Adult, Childhood, Infancy
- Inheritance
- Autosomal dominant, Autosomal recessive
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
18Sometimes5–29%
25- Acute hepatic failure
- Amyloidosis
- Anxiety
- Arrhythmia
- Ascites
- Depression
- Elevated erythrocyte sedimentation rate
- Gastrointestinal infarctions
and 17 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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