Amyloid deposition

What it means

Pathologic deposits of specific fibrillar protein aggregates with distinct microscopic properties, particularly affinity for the dye Congo red with typical birefringence.

Amyloid deposition is associated with amyloidosis, the pathologic process or disease caused by the tissue deposition of amyloid, often leading to organ dysfunction. This term, and its descendents, refer to the amyloid deposition (the phenotypic feature). Other clinical manifestations of amyloidosis should be coded separately.

In everyday care

Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:

Rare diseases that can present with this8

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Amyloid disease · Amyloidosis