Rare diseases · Sign or symptom
Increased total leukocyte count
Elevated white blood count
HP:0001974
What it means
An abnormal increase in the number of leukocytes in the blood.
Rare diseases that can present with this82
Very common80–99%
9- Acute generalized exanthematous pustulosis
- Acute myelomonocytic leukemia
- Adult-onset Still disease
- Autosomal dominant hereditary chronic pancreatitis
- Colchicine poisoning
- Infantile LAD-like disease due to RAC2 deficiency
- Leukocyte adhesion deficiency type II
- Staphylococcal necrotizing pneumonia
- Systemic capillary leak syndrome
Common30–79%
41- Acute monoblastic/monocytic leukemia
- Acute peripheral arterial occlusion
- Aggressive systemic mastocytosis
- Beta-ketothiolase deficiency
- Chronic myeloid leukemia
- CINCA syndrome
- Cogan syndrome
- Cryptogenic organizing pneumonia
- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- Eosinophilic gastroenteritis
- Familial Mediterranean fever
- Generalized pustular psoriasis
- Heme oxygenase-1 deficiency
- Hemorrhagic fever-renal syndrome
- Herpes simplex virus encephalitis
- High altitude pulmonary edema
- Idiopathic chronic eosinophilic pneumonia
- Idiopathic hypereosinophilic syndrome
- Infection-related hemolytic uremic syndrome
- Isolated mesenteric vein thrombosis
- Juvenile temporal arteritis
- Kawasaki disease
- Leukocyte adhesion deficiency
- Lujo hemorrhagic fever
- Majeed syndrome
- Necrotizing enterocolitis
- Neuroleptic malignant syndrome
- Omenn syndrome
- Pyomyositis
- Relapsing fever
- Schnitzler syndrome
- Sepsis in premature infants
- Shigellosis
- Sickle cell anemia
- Subacute inflammatory demyelinating polyneuropathy
- Sweet syndrome
- Systemic mastocytosis with associated hematologic neoplasm
- TAFRO syndrome
- Tularemia
- Tumor necrosis factor receptor 1 associated periodic syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: High white blood count · Increased blood leukocyte number · Leukocytosis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.