Rare diseases · Sign or symptom
Abdominal pain
Pain in stomach
HP:0002027
What it means
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Abdominal pain can be crampy, achy, dull, intermittent or sharp. The terms stomach ache and stomach cramps are nonmedical terms often used to describe pain in the mid- or upper abdominal area, even though it is not the case that the (smooth) muscles of the stomach or the abdomen have cramps. Stomach pain is another layperson term commonly used to refer to abdominal pain.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this247
Very common80–99%
52- Acute adrenal insufficiency
- Acute intermittent porphyria
- Addison disease
- Adenocarcinoma of the anal canal
- Anterior cutaneous nerve entrapment syndrome
- Autosomal dominant hereditary chronic pancreatitis
- Botulism
- Cap polyposis
- Carney triad
- Cholestasis-lymphedema syndrome
- Congenital fibrinogen deficiency
- Congenital sucrase-isomaltase deficiency
- Cutaneous mastocytosis-deafness-microtia syndrome
- Desmoplastic small round cell tumor
- Fabry disease
- Familial colorectal cancer Type X
- Familial Mediterranean fever
- Familial pancreatic carcinoma
- Foodborne botulism
- Hepatic veno-occlusive disease
- Hereditary angioedema type 1
- Hereditary coproporphyria
- Hereditary fructose intolerance
- Hirschsprung disease
- Hyperimmunoglobulinemia D with periodic fever
- Immunoglobulin A vasculitis
- Isolated mesenteric vein thrombosis
- Ketamine-induced biliary dilatation
- Late-onset isolated ACTH deficiency
- Lynch syndrome
- Lysosomal acid lipase deficiency
- Malakoplakia
- Malignant peritoneal mesothelioma
- Mitochondrial neurogastrointestinal encephalomyopathy
- Nodular non-suppurative panniculitis
- Ovarian fibroma
- Ovarian fibrothecoma
- Ovarian hyperstimulation syndrome
- Pediatric hepatocellular carcinoma
- Peripheral demyelinating neuropathy-central dysmyelinating leukodystrophy-Waardenburg syndrome-Hirschsprung disease
- Peritoneal inclusion cyst
- Polycythemia vera
- Primary effusion lymphoma
- Primary peritoneal carcinoma
- Shigellosis
- Short stature due to GHSR deficiency
- Squamous cell carcinoma of the anal canal
- Tumor necrosis factor receptor 1 associated periodic syndrome
- Typhoid
- Variegate porphyria
- Whipple disease
- Williams syndrome
Common30–79%
28- AA amyloidosis
- Adiposis dolorosa
- Adrenocortical carcinoma
- Adult-onset Still disease
- Aggressive systemic mastocytosis
- Alpha-heavy chain disease
- Alveolar echinococcosis
- American trypanosomiasis
- Angiostrongyliasis
- Aseptic abscess syndrome
- Autoimmune hepatitis
- Autosomal dominant hypocalcemia
- Autosomal dominant severe congenital neutropenia
- Bacterial toxic-shock syndrome
- Behçet disease
- Budd-Chiari syndrome
- Carney-Stratakis syndrome
- Caroli disease
- Caroli syndrome
- Castleman disease
- Chronic diarrhea due to glucoamylase deficiency
- Congenital primary megaureter
- Crimean-Congo hemorrhagic fever
- Cronkhite-Canada syndrome
- Cryoglobulinemic vasculitis
- Cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk
- Dengue fever
- Dent disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Abdominal discomfort · Gastro pain · Gastrointestinal pain · Stomach pain · Upset stomach
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.