Rare diseases · Sign or symptom
Arthritis
Joint inflammation
HP:0001369
What it means
Inflammation of a joint.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this122
Very common80–99%
25- Adult-onset Still disease
- Albers-Schönberg osteopetrosis
- Alkaptonuria
- Behçet disease
- Enthesitis-related juvenile idiopathic arthritis
- Fabry disease
- Familial calcium pyrophosphate deposition
- Familial cold urticaria
- Farber disease
- Felty syndrome
- Mixed connective tissue disease
- Muckle-Wells syndrome
- Multicentric osteolysis-nodulosis-arthropathy spectrum
- Multicentric reticulohistiocytosis
- Oligoarticular juvenile idiopathic arthritis
- PAPA syndrome
- Reactive arthritis
- Relapsing polychondritis
- Rheumatic fever
- Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
- Schnitzler syndrome
- Systemic-onset juvenile idiopathic arthritis
- Whipple disease
- Wild type ABeta2M amyloidosis
- Wilson disease
Common30–79%
44- Antisynthetase syndrome
- Autosomal non-syndromic agammaglobulinemia
- Blau syndrome
- Brucellosis
- Chikungunya
- Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Cranio-osteoarthropathy
- Cryoglobulinemic vasculitis
- Dermatomyositis
- Diffuse cutaneous systemic sclerosis
- Dracunculiasis
- Eng-Strom syndrome
- Eosinophilic fasciitis
- Familial Mediterranean fever
- Generalized pustular psoriasis
- Giant cell arteritis
- Granulomatosis with polyangiitis
- Hyperimmunoglobulinemia D with periodic fever
- Hypocomplementemic urticarial vasculitis
- Immunoglobulin A vasculitis
- Juvenile dermatomyositis
- Kawasaki disease
- Lyme disease
- Mild phosphoribosylpyrophosphate synthetase superactivity
- Myalgia-eosinophilia syndrome associated with tryptophan
- Nail-patella syndrome
- Oculocerebrorenal syndrome of Lowe
- Osteochondrosis of the metatarsal bone
- Overlap myositis
- Pachydermoperiostosis
- Polymyositis
- Psoriasis-related juvenile idiopathic arthritis
- Rat-bite fever
- Reynolds syndrome
- Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
- SAPHO syndrome
- Severe phosphoribosylpyrophosphate synthetase superactivity
- Systemic lupus erythematosus
- Takayasu arteritis
- Tenosynovial giant cell tumor
- Tumor necrosis factor receptor 1 associated periodic syndrome
- X-linked agammaglobulinemia
- Zika virus disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.