Rare diseases · Sign or symptom
Acute hepatic failure
Acute liver failure
HP:0006554
What it means
Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.
Rare diseases that can present with this15
Common30–79%
3Sometimes5–29%
9- Acyl-CoA dehydrogenase 9 deficiency
- Budd-Chiari syndrome
- Drug reaction with eosinophilia and systemic symptoms
- Familial Mediterranean fever
- Malignant hyperthermia of anesthesia
- Stevens-Johnson syndrome
- Syndromic multisystem autoimmune disease due to Itch deficiency
- Toxic epidermal necrolysis
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.