Rare diseases · Sign or symptom
Oral leukoplakia
Oral white patch
HP:0002745
What it means
A thickened white patch on the oral mucosa that cannot be rubbed off.
The definition of oral leukoplakia states that the lesion be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. Leukoplakia is a precancerous lesion, i.e. a morphologically altered tissue in which cancer is more likely to occur than in its apparently normal counterpart.
Rare diseases that can present with this6
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: leukokeratosis · Oral idiopathic keratosis · Oral idiopathic leukoplakia · Oral idiopathic white patch · Oral leucoplakia · Oral leukokeratosis · Oral leukoplasia · Oral white plaque
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.