Rare diseases · Sign or symptom
Chest pain
HP:0100749
What it means
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this105
Very common80–99%
10Common30–79%
42- Acetazolamide-responsive myotonia
- Adenocarcinoma of the oesophagus and oesophagogastric junction
- Aspergillosis
- Bronchial neuroendocrine tumor
- Classic Hodgkin lymphoma
- Cocaine intoxication
- Danon disease
- DPM3-CDG
- Ebstein malformation of the tricuspid valve
- Familial aortic dissection
- Familial Mediterranean fever
- Familial thoracic aortic aneurysm and aortic dissection
- Familial thrombocytosis
- Granulomatosis with polyangiitis
- Hereditary atrial fibrillation
- Hereditary pheochromocytoma-paraganglioma
- Idiopathic achalasia
- Idiopathic bronchiectasis
- Idiopathic pulmonary arterial hypertension
- Lassa fever
- Legionnaires disease
- Loeffler endocarditis
- Lujo hemorrhagic fever
- Nocardiosis
- Non-functioning paraganglioma
- Paroxysmal nocturnal hemoglobinuria
- Plague
- Pleural mesothelioma
- Pulmonary alveolar microlithiasis
- Rheumatic fever
- Sarcoidosis
- Sickle cell anemia
- Sporadic pheochromocytoma/secreting paraganglioma
- Squamous cell carcinoma of the esophagus
- Staphylococcal necrotizing pneumonia
- Takayasu arteritis
- Tako-Tsubo cardiomyopathy
- Thymic carcinoma
- Thymic neuroendocrine tumor
- Thymoma
- Variegate porphyria
- X-linked Alport syndrome-diffuse leiomyomatosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Chest discomfort · Thoracic pain
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.