Rare diseases · Sign or symptom
Asthenia
Lack of energy and strength
HP:0025406
What it means
A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
Asthenia is to be distinguished from fatigue, because asthenia refers to a sensation of exhaustion which occurs before any effort. Asthenia is to be distinguished from myasthenia, which means a specific weakness of one or more muscles. Asthenia and fatigue can coexist.
Rare diseases that can present with this26
Common30–79%
16- Acromegaly
- Addison disease
- Adiposis dolorosa
- Adult-onset Still disease
- Alpha-mannosidosis, adult form
- Alpha-mannosidosis, infantile form
- Alveolar echinococcosis
- Brucellosis
- Congenital intrinsic factor deficiency
- Cushing syndrome due to ectopic ACTH secretion
- Familial Mediterranean fever
- Ménétrier disease
- Non-24-hour sleep-wake syndrome
- Pulmonary non-tuberculous mycobacterial infection
- Shigellosis
- Tularemia
Sometimes5–29%
7The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Prostration · Weakness
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.