Rare diseases · Sign or symptom
Erythema
Redness of skin or mucous membrane
HP:0010783
What it means
Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.
Rare diseases that can present with this99
Very common80–99%
46- Acral self-healing collodion baby
- Acrodermatitis enteropathica
- Adult-onset Still disease
- Angioma serpiginosum
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal erythropoietic protoporphyria
- Blau syndrome
- Bullous impetigo
- Bullous pemphigoid
- CHIME syndrome
- Chronic mucocutaneous candidiasis
- Classic mycosis fungoides
- Cutaneous collagenous vasculopathy
- Cutaneous mastocytosis-deafness-microtia syndrome
- Cutaneous small vessel vasculitis
- Dermatitis herpetiformis
- Dermatofibrosarcoma protuberans
- Dermatomyositis
- Drug reaction with eosinophilia and systemic symptoms
- Erosive pustular dermatosis of the scalp
- Erythrokeratodermia variabilis
- Familial cold urticaria
- Fixed drug eruption
- Hailey-Hailey disease
- Hereditary acrokeratotic poikiloderma
- Incontinentia pigmenti
- Jessner lymphocytic infiltration of the skin
- Juvenile dermatomyositis
- Keratolytic winter erythema
- Kindler epidermolysis bullosa
- Microphthalmia with linear skin defects syndrome
- Microscopic polyangiitis
- Mutilating palmoplantar keratoderma with periorificial keratotic plaques
- Netherton syndrome
- Nodular non-suppurative panniculitis
- Primary erythromelalgia
- Progressive symmetric erythrokeratodermia
- Prolidase deficiency
- Quinquaud folliculitis decalvans
- Rothmund-Thomson syndrome type 2
- Scorpion envenomation
- Secondary erythromelalgia
- Sjögren-Larsson syndrome
- Stevens-Johnson syndrome
- Subcorneal pustular dermatosis
- Toxic epidermal necrolysis
Common30–79%
29- Acquired ichthyosis
- Acral peeling skin syndrome
- Chikungunya
- Chronic graft versus host disease
- Complex regional pain syndrome
- Corneodermatoosseous syndrome
- Diffuse palmoplantar keratoderma, Bothnian type
- Familial Mediterranean fever
- Familial tumoral calcinosis
- Focal dermal hypoplasia
- Granulomatous slack skin
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Immunoglobulin A vasculitis
- Kikuchi-Fujimoto disease
- KRT1-related diffuse nonepidermolytic keratoderma
- LIG4 syndrome
- Localized dystrophic epidermolysis bullosa, acral form
- Maculopapular cutaneous mastocytosis
- Mal de Meleda
- Necrobiosis lipoidica
- Neonatal erythroderma-autoinflammation-inflammatory bowel disease syndrome
- Panniculitis-induced localized lipodystrophy
- Pemphigus foliaceus
- Pressure-induced localized lipoatrophy
- Snakebite envenomation
- Tumor necrosis factor receptor 1 associated periodic syndrome
- VIPoma
- Vulvovaginal gingival syndrome
- Xeroderma pigmentosum
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.