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Start free with EleplanPediatric-onset Graves disease
ORPHA:525731Disease
Also called Pediatric-onset Basedow disease
What it is
A rare endocrine disease characterized by the presence of serum autoantibodies against thyroid-stimulating hormone receptors, leading to increased thyroid hormone production and secretion, causing diffuse toxic goiter. Patients present in childhood with signs of thyrotoxicosis (such as tachycardia, weight loss, hand tremor, and sweating), diffuse enlargement of the thyroid gland, and orbitopathy. Additional signs and symptoms include decreased academic and athletic performance, accelerated growth, restlessness, fatigue, sensitivity to heat, and amenorrhea, among others.
Key facts
- Age of onset
- Adolescent, Childhood, Infancy
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Very common80–99%
5- Autoimmunity
- Graves diseaseDiagnostic criterion
- Increased circulating thyroxine levelDiagnostic criterion
- Sinus tachycardia
- Thyrotoxicosis with diffuse goiterDiagnostic criterion
Common30–79%
24- Abnormal eyelid morphology
- Accelerated skeletal maturation
- Anti-thyroid peroxidase antibody positivity
- Diarrhea
- Elevated circulating hepatic transaminase concentration
- Emotional lability
- Failure to thrive
- Flushing
- GoiterDiagnostic criterion
- Hepatomegaly
- Hyperactivity
- Hyperhidrosis
- Hyperkinetic movements
- Increased circulating free T3
- Insomnia
- Irritability
- Palpitations
- Polydipsia
- Polyphagia
- ProptosisDiagnostic criterion
- Puberty and gonadal disorders
- Small anterior fontanelle
- Splenomegaly
- Tremor
Sometimes5–29%
12- Atrial fibrillation
- Atypical behavior
- Craniosynostosis
- Episcleritis
- Hypertension
- Increased fetal movement
- Intrauterine growth retardation
- Jaundice
and 4 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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