Rare diseases · Sign or symptom
Accelerated skeletal maturation
Advanced bone age
HP:0005616
What it means
An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.
Rare diseases that can present with this45
Very common80–99%
14- Acrodysostosis
- Blomstrand lethal chondrodysplasia
- Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
- DDOST-CDG
- Desbuquois syndrome
- Dysplasia epiphysealis hemimelica
- Familial peripheral male-limited precocious puberty
- Heart defects-limb shortening syndrome
- Insulin-resistance syndrome type A
- Malan overgrowth syndrome
- Marshall-Smith syndrome
- Phelan-McDermid syndrome
- Pituitary gigantism
- Weaver syndrome
Common30–79%
18- Aromatase excess syndrome
- Beckwith-Wiedemann syndrome
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Familial hyperthyroidism due to mutations in TSH receptor
- Greig cephalopolysyndactyly syndrome
- McCune-Albright syndrome
- Monosomy 9q22.3 syndrome
- Multiple epiphyseal dysplasia type 4
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Obesity due to melanocortin 4 receptor deficiency
- PDE4D haploinsufficiency syndrome
- Pediatric-onset Graves disease
- Prader-Willi syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Sotos syndrome
- Wiedemann-Steiner syndrome
- XYLT1-CDG
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Early bone maturation · Premature epiphyseal closure · Premature epiphyseal ossification · Premature fusion of the epiphyseal growth plate
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.