Rare diseases · Sign or symptom
Emotional lability
HP:0000712
What it means
Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or disproportionate to events and circumstances.
Rare diseases that can present with this70
Very common80–99%
5Common30–79%
29- Acrodermatitis enteropathica
- Acute liver failure
- Alexander disease
- Amyotrophic lateral sclerosis
- Atypical pantothenate kinase-associated neurodegeneration
- Autosomal recessive spastic paraplegia type 11
- CADASIL
- Cushing disease
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Cushing syndrome due to ectopic ACTH secretion
- Fatal familial insomnia
- Glioblastoma
- Inherited Creutzfeldt-Jakob disease
- Intellectual disability-epilepsy-extrapyramidal syndrome
- Lafora disease
- Leukoencephalopathy with calcifications and cysts
- Metachromatic leukodystrophy, adult form
- Neuroferritinopathy
- Obesity due to leptin receptor gene deficiency
- PANDAS
- Pediatric-onset Graves disease
- Progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome
- Progressive supranuclear palsy
- Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
- Rubinstein-Taybi syndrome due to CREBBP mutations
- Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
- Severe primary trimethylaminuria
- Stiff person spectrum disorder
- Sydenham chorea
Sometimes5–29%
35- 17q24.2microdeletion syndrome
- Alternating hemiplegia of childhood
- Autoerythrocyte sensitization syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal recessive spastic ataxia-optic atrophy-dysarthria syndrome
- Autosomal recessive spastic paraplegia type 20
- Bardet-Biedl syndrome
- Bartter syndrome type 4
and 27 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Can't control feelings · Emotional instability · Mood lability
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.