Rare diseases · Sign or symptom
Tremor
HP:0001337
What it means
An unintentional, oscillating to-and-fro muscle movement about a joint axis.
Tremor is differentiated from other involuntary movement disorders, such as chorea, athetosis, ballism, tics, and myoclonus, by its repetitive, stereotyped movements of a regular amplitude and frequency. Clonus, unlike tremor, represents a rhythmic movement, which is increased by muscle stretching.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this179
Very common80–99%
13- Angelman syndrome
- Ataxia-telangiectasia
- Autosomal recessive malignant osteopetrosis
- Brain dopamine-serotonin vesicular transport disease
- Congenital hyperinsulinism due to HNF4A deficiency
- DDOST-CDG
- Insulinoma
- Non-insulinoma pancreatogenous hypoglycemia syndrome
- Perry syndrome
- Primary orthostatic tremor
- Proximal 16p11.2 microduplication syndrome
- Spinocerebellar ataxia type 27A
- Williams syndrome
Common30–79%
63- 12q14microdeletion syndrome
- 47,XYY syndrome
- 48,XXYY syndrome
- 4H leukodystrophy
- Adult-onset autosomal dominant leukodystrophy
- Alexander disease
- Amish nemaline myopathy
- Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Autosomal spastic paraplegia type 58
- Beta-propeller protein-associated neurodegeneration
- Bilateral striopallidodentate calcinosis
- Cataract-ataxia-deafness syndrome
- Citrullinemia type II
- CLN12 disease
- Cockayne syndrome type 1
- Corticobasal syndrome
- Dopa-responsive dystonia due to sepiapterin reductase deficiency
- Dystonia-parkinsonism-hypermanganesemia syndrome
- Encephalitis lethargica
- Episodic ataxia with slurred speech
- Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
- GM1 gangliosidosis
- Hartnup disease
- Hemiparkinsonism-hemiatrophy syndrome
- Hereditary motor and sensory neuropathy, Okinawa type
- Inherited Creutzfeldt-Jakob disease
- Leukoencephalopathy-spondyloepimetaphyseal dysplasia syndrome
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
- Mercury poisoning
- Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
- Multiple congenital anomalies-hypotonia-seizures syndrome
- NAD(P)HX epimerase deficiency
- Neurodevelopmental delay-seizures-ophthalmic anomalies-osteopenia-cerebellar atrophy syndrome
- Neuroectodermal melanolysosomal disease
- Neuroleptic malignant syndrome
- Nipah virus disease
- O'Sullivan-McLeod syndrome
- Pediatric-onset Graves disease
- PLA2G6-related neurodegeneration, adult-onset
- Primary dystonia, DYT2 type
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
- Progressive supranuclear palsy-corticobasal syndrome
- Progressive supranuclear palsy-predominant parkinsonism syndrome
- Pyruvate dehydrogenase deficiency
- Sandhoff disease, adult form
- Sensorineural hearing loss-early graying-essential tremor syndrome
- Serotonin syndrome
- Sialidosis type 1
- Sialidosis type 2
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
- Spinocerebellar ataxia type 21
- Spinocerebellar ataxia type 37
- Spinocerebellar ataxia with epilepsy
- Spontaneous periodic hypothermia
- Thyrotoxic periodic paralysis
- TSH-secreting pituitary adenoma
- Visual snow syndrome
- Wilson disease
- X-linked intellectual disability, Cabezas type
- X-linked intellectual disability-psychosis-macroorchidism syndrome
- X-linked intellectual disability-short stature-overweight syndrome
- Young-onset Parkinson disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tremors
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.