Rare diseases · Sign or symptom
Palpitations
Missed heart beat
HP:0001962
What it means
A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.
Rare diseases that can present with this67
Common30–79%
34- Acquired methemoglobinemia
- Adrenocortical carcinoma
- Adrenocortical carcinoma with pure aldosterone hypersecretion
- Atrial septal defect, coronary sinus type
- Atrial septal defect, ostium primum type
- Atrial septal defect, ostium secundum type
- Atrial septal defect, sinus venosus type
- Autoimmune hemolytic anemia, warm type
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Catecholaminergic polymorphic ventricular tachycardia
- Chronic thromboembolic pulmonary hypertension
- Congenital Gerbode defect
- Congenital short QT syndrome
- Ebstein malformation of the tricuspid valve
- Eisenmenger syndrome
- Familial idiopathic dilatation of the right atrium
- Glycogen storage disease with severe cardiomyopathy due to glycogenin deficiency
- Hemorrhagic fever-renal syndrome
- Hereditary atrial fibrillation
- Hereditary pheochromocytoma-paraganglioma
- Hyperinsulinism due to HNF1A deficiency
- Hyperinsulinism due to UCP2 deficiency
- Laubry-Pezzi syndrome
- Loeffler endocarditis
- Multiple endocrine neoplasia type 2
- Myelodysplastic neoplasm with increased blasts
- Non-functioning paraganglioma
- Partial atrioventricular septal defect
- Pediatric-onset Graves disease
- Peripartum cardiomyopathy
- Primary triglyceride deposit cardiomyovasculopathy
- Sporadic pheochromocytoma/secreting paraganglioma
- TSH-secreting pituitary adenoma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Heart palpitations · Skipped heart beat
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.