Rare diseases · Sign or symptom
Polydipsia
Extreme thirst
HP:0001959
What it means
Excessive thirst manifested by excessive fluid intake.
Rare diseases that can present with this36
Very common80–99%
8Common30–79%
10- Apparent mineralocorticoid excess
- Arginine vasopressin resistance
- EAST syndrome
- Hyperparathyroidism-jaw tumor syndrome
- Panhypophysitis
- Parathyroid carcinoma
- Pediatric-onset Graves disease
- Primary hyperaldosteronism-seizures-neurological abnormalities syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Senior-Boichis syndrome
Sometimes5–29%
16- Autosomal recessive polycystic kidney disease
- Distal renal tubular acidosis
- Familial cold urticaria
- Familial hyperaldosteronism type I
- Familial hyperaldosteronism type III
- HNF1B-related autosomal dominant tubulointerstitial kidney disease
- Juvenile nephropathic cystinosis
- Kleine-Levin syndrome
and 8 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.