Rare diseases · Sign or symptom
Anti-thyroid peroxidase antibody positivity
HP:0025379
What it means
The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase.
Thyroid peroxidase (TPO) antibody positivity is found in most patients with chronic lymphocytic thyroiditis (Hashimoto disease) and over half of patients with Graves disease.
Rare diseases that can present with this10
Common30–79%
9- IgG4-related retroperitoneal fibrosis
- IgG4-related thyroid disease
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- Immune thrombocytopenia
- Pediatric-onset Graves disease
- Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta
- Syndromic multisystem autoimmune disease due to Itch deficiency
- T-B-NK- severe combined immunodeficiency due to adenosine deaminase deficiency
- Thyroid hemiagenesis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Anti-TPO antibody positivity · Antimicrosomal antibodies · Antimicrosomal antibody positivity · TPOAbs
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.