Rare diseases · Sign or symptom
Congestive heart failure
Cardiac failure
HP:0001635
What it means
The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this158
Very common80–99%
13- AL amyloidosis
- Arterial tortuosity syndrome
- Atypical Werner syndrome
- Chronic thromboembolic pulmonary hypertension
- Endocardial fibroelastosis
- Fabry disease
- Hemoglobin Bart's fetalis syndrome
- Incessant infant ventricular tachycardia
- LMNA-related cardiocutaneous progeria syndrome
- Maternal uniparental disomy of chromosome X syndrome
- Sensorineural deafness with dilated cardiomyopathy
- Tetrasomy 5p syndrome
- Wild type ATTR amyloidosis
Common30–79%
40- Abnormal origin of right or left pulmonary artery from the aorta
- Acyl-CoA dehydrogenase 9 deficiency
- Alpha-thalassemia
- Aortic arch interruption
- Aorto-ventricular tunnel
- Autosomal recessive cutis laxa type 1
- Cardiogenic shock
- Cardiomyopathy-cataract-hip spine disease syndrome
- Colchicine poisoning
- Complete atrioventricular septal defect
- Congenital Gerbode defect
- Congenital left ventricular aneurysm
- Congenitally uncorrected transposition of the great arteries
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome
- Congenital pulmonary lymphangiectasia
- Coronary arterial fistula
- Desminopathy
- DK1-CDG
- Familial isolated dilated cardiomyopathy
- Fixed subaortic stenosis
- Hereditary ATTR amyloidosis
- Hereditary progressive cardiac conduction defect
- Idiopathic giant cell myocarditis
- Idiopathic pulmonary arterial hypertension
- Kidney tubulopathy-dilated cardiomyopathy syndrome
- Laubry-Pezzi syndrome
- Loeffler endocarditis
- Mitochondrial DNA-related cardiomyopathy and hearing loss
- Mitochondrial trifunctional protein deficiency
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Naxos disease
- Peripartum cardiomyopathy
- Scimitar syndrome
- Spinocerebellar ataxia type 7
- TMEM70-related mitochondrial encephalo-cardio-myopathy
- Uhl anomaly
- Univentricular heart
- Werner syndrome
- X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome
- X-linked intellectual disability-psychosis-macroorchidism syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Cardiac failures · Cardiac insufficiency · CHF · Chronic heart failure · Heart failure
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.