Rare diseases · Sign or symptom
Hyperactivity
More active than typical
HP:0000752
What it means
Hyperactivity is a condition characterized by constant and unusually high levels of activity, even in situations where it is deemed inappropriate.
Rare diseases that can present with this88
Very common80–99%
6Common30–79%
31- 13q12.3microdeletion syndrome
- 16p11.2p12.2microdeletion syndrome
- 19p13.12microdeletion syndrome
- 2q23.1microdeletion syndrome
- 47,XYY syndrome
- 7q11.23microduplication syndrome
- Angelman syndrome due to maternal 15q11q13 deletion
- ANK3-related intellectual disability-sleep disturbance syndrome
- Birk-Barel syndrome
- CK syndrome
- Epilepsy with myoclonic-atonic seizures
- Familial gestational hyperthyroidism
- Familial hyperthyroidism due to mutations in TSH receptor
- FRAXE intellectual disability
- Inverted duplicated chromosome 15 syndrome
- Juvenile Huntington disease
- Lennox-Gastaut syndrome
- MORM syndrome
- Mucopolysaccharidosis type 3
- Pediatric-onset Graves disease
- Phelan-McDermid syndrome
- Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta
- Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
- Tuberous sclerosis complex
- White-Sutton syndrome
- Wiedemann-Steiner syndrome
- X-linked creatine transporter deficiency
- X-linked intellectual disability-acromegaly-hyperactivity syndrome
- X-linked intellectual disability-hypotonia-movement disorder syndrome
- X-linked intellectual disability, Stocco Dos Santos type
- Xq25microduplication syndrome
Sometimes5–29%
43- 16p12.1p12.3triplication syndrome
- 19p13.3microduplication syndrome
- 21q22.11q22.12microdeletion syndrome
- 7q31microdeletion syndrome
- 8q24.3microdeletion syndrome
- Angelman syndrome due to imprinting defect in 15q11-q13
- Autism spectrum disorder due to AUTS2 deficiency
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder
and 35 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperactive behavior · Hyperactive behaviour · Hyperkinetic disorder
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.